Article
Inhibitors of the p53-Mdm2 interaction increase programmed cell death and produce abnormal phenotypes in the placozoon Trichoplax adhaerens (F.E. Schulze).
Development genes and evolution - 1 Mar 2014
von der Chevallerie Karolin, Rolfes Sarah, Schierwater Bernd
Abstract excerpt
Recent identification of genes homologous to human p53 and Mdm2 in the basal phylum Placozoa raised the question whether the network undertakes the same functions in the most primitive metazoan organism as it does in more derived animals. Here, we describe inhibition experiments on p53/Mdm2 inter...
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