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Article

The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics - 1 Jan 2000

Kuchtey John, Kuchtey Rachel W

Abstract excerpt

Microfibrils are macromolecular aggregates located in the extracellular matrix of both elastic and nonelastic tissues that have essential functions in formation of elastic fibers and control of signaling through the transforming growth factor beta (TGFβ) family of cytokines. Elevation of systemic...

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Source

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Identifiers

PMID: 24521159
DOI: 10.1089/jop.2013.0184
PMCID: PMC3991966

Genes

ADAMTS10
FBN1
LOXL1
LTBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24521159-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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