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Article

The fallopian tube as the origin of high grade serous ovarian cancer: review of a paradigm shift.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC - 1 Feb 2014

Reade Clare J, McVey Ruaidhrí M, Tone Alicia A, Finlayson Sarah J, McAlpine Jessica N, Fung-Kee-Fung Michael, Ferguson Sarah E

Abstract excerpt

Research published over the past 10 years has suggested that most "ovarian cancer," and specifically the high-grade serous carcinoma (HGSC) subtype of ovarian cancer, actually originates in the fallopian tube. In this review, we examine the evidence supporting the tubal origin hypothesis for HGSC, and discuss the clinical implications of our improved understanding of the pathogenesis of ovarian cancer. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24518912
DOI: 10.1016/S1701-2163(15)30659-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The fallopian tube as the origin of high grade serous ovarian cancer: review of a paradigm shift.PMID 24518912Read ↗

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