Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exon-skipping antisense oligonucleotides to correct missplicing in neurogenetic diseases.

Nucleic acid therapeutics - 1 Feb 2014

Siva Kavitha, Covello Giuseppina, Denti Michela A

Abstract excerpt

Alternative splicing is an important regulator of the transcriptome. However, mutations may cause alteration of splicing patterns, which in turn leads to disease. During the past 10 years, exon skipping has been looked upon as a powerful tool for correction of missplicing in disease and progress has been made towards clinical trials. In this review, we discuss the use of antisense oligonucleotides to correct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood-Brain Barrier
Share to Congenital Disorders of Glycosylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hereditary Central Nervous System Demyelinating Diseases

Share to Neurofibromatoses

Share to Niemann-Pick Disease, Type C

Share to Pelizaeus-Merzbacher Disease

Share to Phosphotransferases (Phosphomutases)

Source

Open in PubMed Open full text

Identifiers

PMID: 24506781
DOI: 10.1089/nat.2013.0461
PMCID: PMC3922311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exon-skipping antisense oligonucleotides to correct missplicing in neurogenetic diseases.PMID 24506781Read ↗

Neurodegenerative diseases: a hotbed for splicing defects and the potential therapiesSemantic proximity Read ↗

Antisense oligonucleotides and their applications in rare neurological diseasesSemantic proximity Read ↗

Expansion of Splice-Switching Therapy with Antisense OligonucleotidesSemantic proximity Read ↗

Overview on applications of antisense-mediated exon skipping.Semantic proximity Read ↗

Antisense-mediated exon skipping: Taking advantage of a trick from Mother Nature to treat rare genetic diseasesSemantic proximity Read ↗

The expanding application of antisense oligonucleotides to neurodegenerative diseasesSemantic proximity Read ↗

Clinical applications of exon-skipping antisense oligonucleotides in neuromuscular diseasesSemantic proximity Read ↗

Splice-switching antisense oligonucleotides for pediatric neurological disordersSemantic proximity Read ↗

Genetic therapies for RNA mis-splicing diseases.Semantic proximity Read ↗

Making antisense of splicing.Semantic proximity Read ↗

Antisense Oligonucleotide-Mediated Exon-skipping Therapies: Precision Medicine Spreading from Duchenne Muscular DystrophySemantic proximity Read ↗

Possibilities and limitations of antisense oligonucleotide therapies for the treatment of monogenic disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.