Maintaining skeletal muscle mass: lessons learned from hibernation.

Abstract excerpt

Muscle disuse and starvation are often associated with a catabolic response leading to a dramatic loss of skeletal muscle mass. Hibernating animals represent a unique situation where muscle mass is maintained despite prolonged periods of immobilization and lack of nutrition. We analysed the molecular pathways upregulated during hibernation in an obligate hibernator, the 13-lined ground squirrel (Ictidomys...

Topics

• Animals
• Disease Models, Animal
• Energy Metabolism
• Genotype
• Hibernation
• Humans
• Immediate-Early Proteins
• Mice, Knockout
• Muscle, Skeletal
• Muscular Atrophy
• Organ Size
• Phenotype