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Article

Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.

Neurology - 4 Feb 2014

Fitzmaurice Arthur G, Rhodes Shannon L, Cockburn Myles, Ritz Beate, Bronstein Jeff M

Abstract excerpt

OBJECTIVE: The objective of this study was to determine whether environmental and genetic alterations of neuronal aldehyde dehydrogenase (ALDH) enzymes were associated with increased Parkinson disease (PD) risk in an epidemiologic study. METHODS: A novel ex vivo assay was developed to identify pesticides that can inhibit neuronal ALDH activity. These were investigated for PD associations in a population-based...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24491970
DOI: 10.1212/WNL.0000000000000083
PMCID: PMC3917685

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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