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Article

Cancer stem cell hypothesis and gastric carcinogenesis: Experimental evidence and unsolved questions

1 Jan 2012

Abstract excerpt

Traditionally, the clonal evolution model has been used to explain gastric cancer (GC) growth dynamics. According to this model, GC cells result from multiple mutations over time resulting in a population of continually diversifying cells. This heterogeneity enables the survival of different clones under particular conditions allowing growth at metastatic locations or resistance to chemotherapeutics. Cancer stem...

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PMID: 22468184
DOI: 10.4251/wjgo.v4.i3.54

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