Article
Identification by digital immunohistochemistry of intratumoral changes of immune infiltrates after vaccine in the absence of modifications of PBMC immune cell subsets.
International journal of cancer - 15 Aug 2014
Farsaci Benedetto, Jochems Caroline, Grenga Italia, Donahue Renee N, Tucker Jo A, Pinto Peter A, Merino Maria J, Heery Christopher R, Madan Ravi A, Gulley James L, Schlom Jeffrey
Abstract excerpt
Preclinical studies have demonstrated that the combination of systemic subcutaneous (s.c.) vaccination with intratumoral (i.t.) vaccination was superior in the induction of antitumor activity vs. vaccination with either route alone. A subsequent phase I study employing i.t.-s.c. vaccination was c...
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