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Article

Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes.

Molecular and cellular biology - 1 Apr 2014

Karki Pratap, Webb Anton, Smith Keisha, Johnson James, Lee Kyuwon, Son Deok-Soo, Aschner Michael, Lee Eunsook

Abstract excerpt

Impairment of astrocytic glutamate transporter (GLT-1; EAAT2) function is associated with multiple neurodegenerative diseases, including Parkinson's disease (PD) and manganism, the latter being induced by chronic exposure to high levels of manganese (Mn). Mn decreases EAAT2 promoter activity and mRNA and protein levels, but the molecular mechanism of Mn-induced EAAT2 repression at the transcriptional level has...

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Identifiers

PMID: 24469401
DOI: 10.1128/MCB.01176-13
PMCID: PMC3993574

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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