Article
ArchiLD: hierarchical visualization of linkage disequilibrium in human populations.
PloS one - 1 Jan 2014
Melchiotti Rossella, Rötzschke Olaf, Poidinger Michael
Abstract excerpt
Linkage disequilibrium (LD) is an essential metric for selecting single-nucleotide polymorphisms (SNPs) to use in genetic studies and identifying causal variants from significant tag SNPs. The explosion in the number of polymorphisms that can now be genotyped by commercial arrays makes the interpretation of triangular correlation plots, commonly used for visualizing LD, extremely difficult in particular when...
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