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Article

Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture.

PloS one - 1 Jan 2014

Gieseck Richard L, Hannan Nicholas R F, Bort Roque, Hanley Neil A, Drake Rosemary A L, Cameron Grant W W, Wynn Thomas A, Vallier Ludovic

Abstract excerpt

Induced pluripotent stem cell derived hepatocytes (IPSC-Heps) have the potential to reduce the demand for a dwindling number of primary cells used in applications ranging from therapeutic cell infusions to in vitro toxicology studies. However, current differentiation protocols and culture methods produce cells with reduced functionality and fetal-like properties compared to adult hepatocytes. We report a culture...

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Identifiers

PMID: 24466060
DOI: 10.1371/journal.pone.0086372
PMCID: PMC3899231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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