Article
Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches.
Acta neurologica Taiwanica - 1 Dec 2013
Ishii Masakazu, Katoh Hirotaka, Onaya Tomomi, Kasai Hideyo, Kawamura Mitsuru, Shimizu Shunichi
Abstract excerpt
PURPOSE: We investigated whether tryptophan hydroxylase 2 (TPH2) gene polymorphisms were involved in the aggravation of migraines due to the overuse of medication. METHODS: Forty-seven migraine patients (6 males and 41 females; 36.4 10.3 years) and 22 MOH patients (1 male and 21 females; 39.6 9.9 years) who had migraines participated in this study. The genotypes for the TPH2 gene polymorphisms (rs4565946,...
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