Article
Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity.
PLoS pathogens - 1 Jan 2014
Full Florian, Jungnickl Doris, Reuter Nina, Bogner Elke, Brulois Kevin, Scholz Brigitte, Stürzl Michael, Myoung Jinjong, Jung Jae U, Stamminger Thomas, Ensser Armin
Abstract excerpt
Nuclear domain 10 (ND10) components are restriction factors that inhibit herpesviral replication. Effector proteins of different herpesviruses can antagonize this restriction by a variety of strategies, including degradation or relocalization of ND10 proteins. We investigated the interplay of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) infection and cellular defense by nuclear domain 10 (ND10) components....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.