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Article

ALK inhibitors of bis-ortho-alkoxy-para-piperazinesubstituted-pyrimidines and -triazines for cancer treatment.

Archives of pharmacal research - 1 Jan 2014

Lee Hyeon Ji, Latif Muhammad, Choe Hyeonjeong, Ali Imran, Lee Heung Kyoung, Yang Eun Hye, Yun Jeong In, Chae Chong Hak, Jung Jae-Kyung, Kim Hyoung Rae, Lee Chong Ock, Park Chi Hoon, Lee Kwangho

Abstract excerpt

Syntheses of various bis-ortho-alkoxy-para-piperazineanilino-pyrimidines and -triazines of KRCA-0008 analogs are described and their structure-activity-relationship to anaplastic lymphoma kinase (ALK) is discussed. 5-trifluoromethyl-2,4-pyrimidine analog (2) seems to be most potent in both biochemical and cellular assay in this study, however it shows inferior mice xenograft activity to Crizotinib presumably due...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24446111
DOI: 10.1007/s12272-013-0323-z

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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