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Pyrroformyl-containing 2,4-diaminopyrimidine derivatives as a new optimization strategy of ALK inhibitors combating mutations.

Bioorganic & medicinal chemistry - 15 Oct 2020

Cao Meng, Chen Yuxiang, Zhao Tianming, Wei Shangfei, Guo Ming, Zhai Xin

Abstract excerpt

Aiming to identify new optimization strategy effective for ALK-mutations, two series of pyrroformyl-containing 2,4-diaminopyrimidine compounds (11a-o, 12a-o) were designed, synthesized and evaluated for their anti-proliferative activities against three cancer cell lines in vitro by MTT assay. The biological evaluations on cellular assay resulted in discovery of compound 11k, which performed considerable activity...

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PMID: 33069079
DOI: 10.1016/j.bmc.2020.115715

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