Article
Functional analyses of three acyl-CoA synthetases involved in bile acid degradation in Pseudomonas putida DOC21.
Environmental microbiology - 1 Jan 2015
Barrientos Álvaro, Merino Estefanía, Casabon Israël, Rodríguez Joaquín, Crowe Adam M, Holert Johannes, Philipp Bodo, Eltis Lindsay D, Olivera Elías R, Luengo José M
Abstract excerpt
Pseudomonas putida DOC21, a soil-dwelling proteobacterium, catabolizes a variety of steroids and bile acids. Transposon mutagenesis and bioinformatics analyses identified four clusters of steroid degradation (std) genes encoding a single catabolic pathway. The latter includes three predicted acyl-CoA synthetases encoded by stdA1, stdA2 and stdA3 respectively. The ΔstdA1 and ΔstdA2 deletion mutants were unable to...
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