Article
The inflammatory gene pathway is not a major contributor to polycystic ovary snydrome.
The Journal of clinical endocrinology and metabolism - 1 Mar 2014
Bhatt Surabhi, Mutharasan Priscilla, Garcia Obed A, Jafari Nadereh, Legro Richard S, Dunaif Andrea, Urbanek Margrit
Abstract excerpt
CONTEXT: Although inflammation is clearly associated with obesity, diabetes, and insulin resistance, the role of chronic inflammation in the etiology of polycystic ovary syndrome (PCOS) is unclear. OBJECTIVE: To determine whether chronic inflammation plays a causal role in the etiology of PCOS, we tested for an association between PCOS and genetic markers mapping to 80 members of the inflammatory pathway. DESIGN:...
Topics
- Case-Control Studies
- Cholesterol, HDL
- Endothelin-1
- Female
- Gene Frequency
- Glucose Tolerance Test
- Humans
- Inflammation
- Polycystic Ovary Syndrome
- Polymorphism, Single Nucleotide