Changes in the clinical impact of high-risk human leukocyte antigen allele mismatch combinations on the outcome of unrelated bone marrow transplantation.

doi:10.1016/j.bbmt.2014.01.003

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Article

Changes in the clinical impact of high-risk human leukocyte antigen allele mismatch combinations on the outcome of unrelated bone marrow transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Apr 2014

Kanda Yoshinobu, Kanda Junya, Atsuta Yoshiko, Fuji Shigeo, Maeda Yoshinobu, Ichinohe Tastuo, Takanashi Minoko, Ohashi Kazuteru, Fukuda Takahiro, Miyamura Koichi, Mori Takehiko, Sao Hiroshi, Kobayashi Naoki, Iwato Koji, Sawada Akihisa, Mori Shinichiro

Abstract excerpt

Several high-risk HLA allele mismatch combinations (HR-MMs) for severe acute graft-versus-host disease (GVHD) have been identified by analyzing transplantation outcomes in Japanese unrelated hematopoietic stem cell transplant recipients. In this study, we analyzed the effects of HR-MMs in 3 transplantation time periods. We confirmed that the incidence of grade III to IV acute GVHD in the HR-MM group was...

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PMID: 24417871
DOI: 10.1016/j.bbmt.2014.01.003

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