Article
Intrasubtype reassortments cause adaptive amino acid replacements in H3N2 influenza genes.
PLoS genetics - 1 Jan 2014
Neverov Alexey D, Lezhnina Ksenia V, Kondrashov Alexey S, Bazykin Georgii A
Abstract excerpt
Reassortments and point mutations are two major contributors to diversity of Influenza A virus; however, the link between these two processes is unclear. It has been suggested that reassortments provoke a temporary increase in the rate of amino acid changes as the viral proteins adapt to new genetic environment, but this phenomenon has not been studied systematically. Here, we use a phylogenetic approach to infer...
Topics
- Amino Acid Substitution
- Evolution, Molecular
- Genetic Variation
- Humans
- Influenza A Virus, H3N2 Subtype
- Influenza, Human
- Phylogeny
- Point Mutation
- Viral Proteins