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Article

CTCF and Rad21 Act as Host Cell Restriction Factors for Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Replication by Modulating Viral Gene Transcription

9 Jan 2014

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) is a human herpesvirus that causes Kaposi's sarcoma and is associated with the development of lymphoproliferative diseases. KSHV reactivation from latency and virion production is dependent on efficient transcription of over eighty lytic cycle genes and viral DNA replication. CTCF and cohesin, cellular proteins that cooperatively regulate gene expression and mediate...

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PMID: 24415941
DOI: 10.1371/journal.ppat.1003880

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CTCF and Rad21 Act as Host Cell Restriction Factors for Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Replication by Modulating Viral Gene TranscriptionPMID 24415941Read ↗

CTCF interacts with the lytic HSV-1 genome to promote viral transcriptionSemantic proximity Read ↗

Chromatinization of the KSHV Genome During the KSHV Life CycleSemantic proximity Read ↗

Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma TissuesSemantic proximity Read ↗

The Chromatin Landscape of Kaposi’s Sarcoma-Associated HerpesvirusSemantic proximity Read ↗

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KSHV RTA utilizes the host E3 ubiquitin ligase complex RNF20/40 to drive lytic reactivationSemantic proximity Read ↗

Kruppel-Associated Box Domain-Associated Protein-1 as a Latency Regulator for Kaposi's Sarcoma-Associated Herpesvirus and Its Modulation by the Viral Protein KinaseSemantic proximity Read ↗

The Open Chromatin Landscape of Kaposi's Sarcoma-Associated HerpesvirusSemantic proximity Read ↗

Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijackingSemantic proximity Read ↗

Epigenetic Regulation of Kaposi’s Sarcoma-Associated Herpesvirus LatencySemantic proximity Read ↗

Rewriting Viral Fate: Epigenetic and Transcriptional Dynamics in KSHV InfectionSemantic proximity Read ↗

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