Article
Arabidopsis accelerated cell death 11, ACD11, is a ceramide-1-phosphate transfer protein and intermediary regulator of phytoceramide levels.
Cell reports - 30 Jan 2014
Simanshu Dhirendra K, Zhai Xiuhong, Munch David, Hofius Daniel, Markham Jennifer E, Bielawski Jacek, Bielawska Alicja, Malinina Lucy, Molotkovsky Julian G, Mundy John W, Patel Dinshaw J, Brown Rhoderick E
Abstract excerpt
The accelerated cell death 11 (acd11) mutant of Arabidopsis provides a genetic model for studying immune response activation and localized cellular suicide that halt pathogen spread during infection in plants. Here, we elucidate ACD11 structure and function and show that acd11 disruption dramatically alters the in vivo balance of sphingolipid mediators that regulate eukaryotic-programmed cell death. In acd11...
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