Article
Human GLTP and mutant forms of ACD11 suppress cell death in the Arabidopsis acd11 mutant.
The FEBS journal - 1 Sept 2008
Petersen Nikolaj H T, McKinney Lea V, Pike Helen, Hofius Daniel, Zakaria Asif, Brodersen Peter, Petersen Morten, Brown Rhoderick E, Mundy John
Abstract excerpt
The Arabidopsis acd11 mutant exhibits runaway, programmed cell death due to the loss of a putative sphingosine transfer protein (ACD11) with homology to mammalian GLTP. We demonstrate that transgenic expression in Arabidopsis thaliana of human GLTP partially suppressed the phenotype of the acd11 null mutant, resulting in delayed programmed cell death development and plant survival. Surprisingly, a GLTP mutant...
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