Article
An integer programming formulation of the parsimonious loss of heterozygosity problem.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Catanzaro Daniele, Labbé Martine, Halldórsson Bjarni V
Abstract excerpt
A loss of heterozygosity (LOH) event occurs when, by the laws of Mendelian inheritance, an individual should be heterozygote at a given site but, due to a deletion polymorphism, is not. Deletions play an important role in human disease and their detection could provide fundamental insights for the development of new diagnostics and treatments. In this paper, we investigate the parsimonious loss of heterozygosity...
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