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Article

Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease.

Gastroenterology - 1 Apr 2014

Costea Irina, Mack David R, Lemaitre Rozenn N, Israel David, Marcil Valerie, Ahmad Ali, Amre Devendra K

Abstract excerpt

Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and...

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Source

Identifiers

PMID: 24406470
DOI: 10.1053/j.gastro.2013.12.034

Genes

FADS2
FADS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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