Article
MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors.
Pigment cell & melanoma research - 1 May 2014
Berwick Marianne, MacArthur Jamie, Orlow Irene, Kanetsky Peter, Begg Colin B, Luo Li, Reiner Anne, Sharma Ajay, Armstrong Bruce K, Kricker Anne, Cust Anne E, Marrett Loraine D, Gruber Stephen B, Anton-Culver Hoda, Zanetti Roberto, Rosso Stefano, Gallagher Richard P, Dwyer Terence, Venn Alison, Busam Klaus, From Lynn, White Kirsten, Thomas Nancy E
Abstract excerpt
A rare germline variant in the microphthalmia-associated transcription factor (MITF) gene, E318K, has been reported as associated with melanoma. We confirmed its independent association with melanoma [odds ratio (OR) 1.7, 95% confidence interval (CI) = 1.1, 2.7, P = 0.03]; adjusted for age, sex, center, age × sex interaction, pigmentation characteristics, family history of melanoma, and nevus density). In...
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