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Article

The truncated splice variants, <i>NT</i>-<i>PGC</i>-<i>1α</i> and <i>PGC</i>-<i>1α4</i>, increase with both endurance and resistance exercise in human skeletal muscle

1 Nov 2013

Abstract excerpt

Recently, a truncated peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) splice variant, PGC-1α4, that originates from the alternative promoter was shown to be induced by resistance exercise and to elicit muscle hypertrophy without coactivation of "classical" PGC-1α targets involved in mitochondrial biogenesis and angiogenesis. In order to test if distinct physiological adaptations are...

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PMID: 24400142
DOI: 10.1002/phy2.140

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