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Article

Diminished Virulence of an Alpha-Toxin Mutant of<i>Staphylococcus aureus</i>in Experimental Brain Abscesses

1 Nov 2001

Abstract excerpt

Staphylococcus aureus is one of the major etiologic agents of brain abscesses in humans, occasionally leading to focal neurological deficits and even death. The objective of the present study was to identify key virulence determinants contributing to the pathogenesis of S. aureus in the brain using a murine brain abscess model. The importance of virulence factor production in disease development was demonstrated...

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PMID: 11598065
DOI: 10.1128/iai.69.11.6902-6911.2001

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