Article
A post-GWAS replication study confirming the PTK2 gene associated with milk production traits in Chinese Holstein.
PloS one - 1 Jan 2013
Wang Haifei, Jiang Li, Liu Xuan, Yang Jie, Wei Julong, Xu Jingen, Zhang Qin, Liu Jian-Feng
Abstract excerpt
Our initial genome-wide association study (GWAS) demonstrated that two SNPs (ARS-BFGL-NGS-33248, UA-IFASA-9288) within the protein tyrosine kinase 2 (PTK2) gene were significantly associated with milk production traits in Chinese Holstein dairy cattle. To further validate if the statistical evidence provided in GWAS were true-positive findings, a replication study was performed herein through genotype-phenotype...
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