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Article

Phenome-wide association studies on a quantitative trait: application to TPMT enzyme activity and thiopurine therapy in pharmacogenomics.

PLoS computational biology - 1 Jan 2013

Neuraz Antoine, Chouchana Laurent, Malamut Georgia, Le Beller Christine, Roche Denis, Beaune Philippe, Degoulet Patrice, Burgun Anita, Loriot Marie-Anne, Avillach Paul

Abstract excerpt

Phenome-Wide Association Studies (PheWAS) investigate whether genetic polymorphisms associated with a phenotype are also associated with other diagnoses. In this study, we have developed new methods to perform a PheWAS based on ICD-10 codes and biological test results, and to use a quantitative trait as the selection criterion. We tested our approach on thiopurine S-methyltransferase (TPMT) activity in patients...

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Share to TPMT gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24385893
DOI: 10.1371/journal.pcbi.1003405
PMCID: PMC3873228

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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