Article
The pharmacogenetics of antiplatelet agents: towards personalized therapy?
Nature reviews. Cardiology - 9 Aug 2011
Ahmad Tariq, Voora Deepak, Becker Richard C
Abstract excerpt
Considerable variability exists in how individual patients respond to oral antiplatelet therapy, specifically to aspirin and to P2Y(12)-receptor inhibitors such as clopidogrel. This variability translates to differences in clinical outcomes and might in part be as a result of common variation within genes that are involved in the absorption, metabolic activation, and biological activity of these medications. The...
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