Article
Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila.
FEBS letters - 31 Jan 2014
Nagy Péter, Hegedűs Krisztina, Pircs Karolina, Varga Ágnes, Juhász Gábor
Abstract excerpt
The Atg2-Atg18 complex acts in parallel to Atg8 and regulates Atg9 recycling from phagophore assembly site (PAS) during autophagy in yeast. Here we show that in Drosophila, both Atg9 and Atg18 are required for Atg8a puncta formation, unlike Atg2. Selective autophagic degradation of ubiquitinated...
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