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Article

Reactivation of Chromosomally Integrated Human Herpesvirus-6 by Telomeric Circle Formation

19 Dec 2013

Abstract excerpt

More than 95% of the human population is infected with human herpesvirus-6 (HHV-6) during early childhood and maintains latent HHV-6 genomes either in an extra-chromosomal form or as a chromosomally integrated HHV-6 (ciHHV-6). In addition, approximately 1% of humans are born with an inheritable form of ciHHV-6 integrated into the telomeres of chromosomes. Immunosuppression and stress conditions can reactivate...

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PMID: 24367281
DOI: 10.1371/journal.pgen.1004033

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