Article
Interaction of rabies virus P-protein with STAT proteins is critical to lethal rabies disease.
The Journal of infectious diseases - 1 Jun 2014
Wiltzer Linda, Okada Kazuma, Yamaoka Satoko, Larrous Florence, Kuusisto Henna Veera, Sugiyama Makoto, Blondel Danielle, Bourhy Hervé, Jans David Andrew, Ito Naoto, Moseley Gregory William
Abstract excerpt
BACKGROUND: Rabies virus (RABV) causes rabies disease resulting in >55,000 human deaths/year. The multifunctional RABV P-protein has essential roles in genome replication, and forms interactions with cellular STAT proteins that are thought to underlie viral antagonism of interferon-dependent immunity. However, the molecular details of P-protein-STAT interaction, and its importance to disease are unresolved....
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