Article
Wilms' tumor suppressor gene mutations in girls with sporadic isolated steroid-resistant nephrotic syndrome.
Genetics and molecular research : GMR - 4 Dec 2013
Yang Y H, Zhao F, Feng D N, Wang J J, Wang C F, Huang J, Nie X J, Xia G Z, Chen G M, Yu Z H
Abstract excerpt
Mutations in the Wilms' tumor suppressor gene (WT1) can lead to syndromic forms of steroid-resistant nephrotic syndrome (SRNS) such as Denys-Drash or Frasier syndrome and can cause isolated SRNS. A mutation within WT1 is a frequent cause of sporadic isolated SRNS in girls. In a worldwide cohort of girls, the rate of occurrence was 10.8%. Previous reports have indicated that in Chinese girls, the detection rate of...
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