Article
Impact of TNF haplotypes in the physical course of acne vulgaris.
Dermatology (Basel, Switzerland) - 1 Jan 2014
Grech Ioanna, Giatrakos Sophia, Damoraki Georgia, Kaldrimidis Philippos, Rigopoulos Dimitrios, Giamarellos-Bourboulis Evangelos J
Abstract excerpt
BACKGROUND: The role of single-nucleotide polymorphisms (SNPs) of the TNF gene in acne vulgaris remains controversial. METHODS: Genomic DNA was isolated from 185 patients with acne vulgaris and 165 healthy controls. SNPs at positions -376, -308 and -238 of the promoter region of TNF were defined. RESULTS: The frequency of the GAG haplotype was greater among patients (16.8%) than among controls with borderline...
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