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Article

Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata.

Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Dec 2012

Grech I, Giatrakou S, Damoraki G, Pistiki A, Kaldrimidis P, Giamarellos-Bourboulis E J, Stavrianeas N

Abstract excerpt

BACKGROUND: Former studies have shown that Propionibacterium acnes may stimulate expression of toll-like receptor 4 (TLR4) in keratinocytes of patients with acne vulgaris. OBJECTIVE: To investigate the impact of single nucleotide polumorphisms (SNPs) of the TLR4 gene in acne vulgaris. METHODS: Genomic DNA was isolated from 191 patients with acne vulgaris and 75 healthy controls. Asp299Gly and Thr399Ile SNPs were...

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Source

Identifiers

PMID: 22085193
DOI: 10.1111/j.1468-3083.2011.04338.x

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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