Article
Pharmacogenetics of taste: turning bitter pills sweet?
Pharmacogenomics - 1 Jan 2014
Nagtegaal Mariëlle J, Swen Jesse J, Hanff Lidwien M, Schimmel Kirsten Jm, Guchelaar Henk-Jan
Abstract excerpt
Poor palatability of oral drug formulations used for young children negatively influences medication intake, resulting in suboptimal treatment. Some children are more sensitive to bitter tastes than others. Bitter tasting status is currently assessed by phenotyping with 6-n-propylthiouracil (PROP) as a bitter probe. Recent studies showed that interindividual differences in PROP sensitivity can be largely...
Topics
- Child
- Drug Compounding
- Female
- Genotype
- Humans
- Pediatrics
- Pharmacogenetics
- Polymorphism, Single Nucleotide
- Propylthiouracil
- Receptors, G-Protein-Coupled
- Taste
- Taste Receptors, Type 2