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Article

No TAP63 promoter mutation is detected in bladder exstrophy-epispadias complex patients.

Journal of pediatric surgery - 1 Dec 2013

Darling Tom, Mahfuz Istiak, White Stefan J, Cheng Wei

Abstract excerpt

BACKGROUND/PURPOSE: Bladder exstrophy-epispadias complex (BEEC) is thought to have a genetic component in its pathogenesis. Previously we found that p63(-/-) mice show increased ventral apoptosis and develop a BEEC phenotype. Down-regulation of the anti-apoptotic ΔNP63 and an up-regulation of pro-apoptotic TAP63 isoforms have been demonstrated in BEEC patient bladder tissues. We have previously shown that...

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Identifiers

PMID: 24314177
DOI: 10.1016/j.jpedsurg.2013.08.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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