Impact of HIV-1 backbone on neutralization sensitivity: neutralization profiles of heterologous envelope glycoproteins expressed in native subtype C and CRF01_AE backbone.

doi:10.1371/journal.pone.0076104

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Article

Impact of HIV-1 backbone on neutralization sensitivity: neutralization profiles of heterologous envelope glycoproteins expressed in native subtype C and CRF01_AE backbone.

PloS one - 1 Jan 2013

Chenine Agnès-Laurence, Wieczorek Lindsay, Sanders-Buell Eric, Wesberry Maggie, Towle Teresa, Pillis Devin M, Molnar Sebastian, McLinden Robert, Edmonds Tara, Hirsch Ivan, O'Connell Robert, McCutchan Francine E, Montefiori David C, Ochsenbauer Christina, Kappes John C, Kim Jerome H, Polonis Victoria R, Tovanabutra Sodsai

Abstract excerpt

Standardized assays to assess vaccine and antiviral drug efficacy are critical for the development of protective HIV-1 vaccines and drugs. These immune assays will be advanced by the development of standardized viral stocks, such as HIV-1 infectious molecular clones (IMC), that i) express a reporter gene, ii) are representative of globally diverse subtypes and iii) are engineered to easily exchange envelope (env)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24312165
DOI: 10.1371/journal.pone.0076104
PMCID: PMC3843658

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