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Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control

5 Dec 2013

Abstract excerpt

Stem cell-based disease modeling presents unique opportunities for mechanistic elucidation and therapeutic targeting. The stable induction of fate-specific differentiation is an essential prerequisite for stem cell-based strategy. Bone morphogenetic protein 2 (BMP-2) initiates receptor-regulated Smad phosphorylation, leading to the osteogenic differentiation of mesenchymal stromal/stem cells (MSC) in vitro;...

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PMID: 24305548
DOI: 10.1038/srep03420

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