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Article

The DNA double-strand break response is abnormal in myeloblasts from patients with therapy-related acute myeloid leukemia.

Leukemia - 1 Jun 2014

Jacoby M A, De Jesus Pizarro R E, Shao J, Koboldt D C, Fulton R S, Zhou G, Wilson R K, Walter M J

Abstract excerpt

The complex chromosomal aberrations found in therapy-related acute myeloid leukemia (t-AML) suggest that the DNA double-strand break (DSB) response may be altered. In this study we examined the DNA DSB response of primary bone marrow cells from t-AML patients and performed next-generation sequencing of 37 canonical homologous recombination (HR) and non-homologous end-joining (NHEJ) DNA repair genes, and a subset...

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Share to Bone Marrow
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Comparative Genomic Hybridization

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Source

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Identifiers

PMID: 24304937
DOI: 10.1038/leu.2013.368
PMCID: PMC4047198

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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