Article
A novel HBV genotypes detecting system combined with microfluidic chip, loop-mediated isothermal amplification and GMR sensors.
Biosensors & bioelectronics - 15 Apr 2014
Zhi Xiao, Deng Min, Yang Hao, Gao Guo, Wang Kan, Fu Hualin, Zhang Yixia, Chen Di, Cui Daxiang
Abstract excerpt
Genotyping of hepatitis B virus (HBV) can be used for clinical effective therapeutic drug-selection. A novel microfluidic biochip for HBV genotyping has been fabricated, for the first time, integrating loop-mediated isothermal amplification (LAMP), line probes assay (LiPA) and giant magnetoresistive (GMR) sensors. Coupling LAMP with LiPA in microfluidic chip shortened reaction time substantially, and combining...
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