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Article

Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death.

Cancer discovery - 1 Oct 2013

Heaphy Christopher M, Yoon Ghil Suk, Peskoe Sarah B, Joshu Corinne E, Lee Thomas K, Giovannucci Edward, Mucci Lorelei A, Kenfield Stacey A, Stampfer Meir J, Hicks Jessica L, De Marzo Angelo M, Platz Elizabeth A, Meeker Alan K

Abstract excerpt

UNLABELLED: Current prognostic indicators are imperfect predictors of outcome in men with clinically localized prostate cancer. Thus, tissue-based markers are urgently needed to improve treatment and surveillance decision-making. Given that shortened telomeres enhance chromosomal instability and such instability is a hallmark of metastatic lesions, we hypothesized that alterations in telomere length in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23779129
DOI: 10.1158/2159-8290.CD-13-0135
PMCID: PMC3797255

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