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Rescue of a Recombinant Machupo Virus from Cloned cDNAs and <i>In Vivo</i> Characterization in Interferon (αβ/γ) Receptor Double Knockout Mice

28 Nov 2013

Abstract excerpt

Machupo virus (MACV) is the etiological agent of Bolivian hemorrhagic fever (BHF), a reemerging and neglected tropical disease associated with high mortality. The prototypical strain of MACV, Carvallo, was isolated from a human patient in 1963, but minimal in vitro and in vivo characterization has been reported. To this end, we utilized reverse genetics to rescue a pathogenic MACV from cloned cDNAs. The...

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PMID: 24284323
DOI: 10.1128/jvi.02925-13

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