Article
Rule-based models of the interplay between genetic and environmental factors in childhood allergy.
PloS one - 1 Jan 2013
Bornelöv Susanne, Sääf Annika, Melén Erik, Bergström Anna, Torabi Moghadam Behrooz, Pulkkinen Ville, Acevedo Nathalie, Orsmark Pietras Christina, Ege Markus, Braun-Fahrländer Charlotte, Riedler Josef, Doekes Gert, Kabesch Michael, van Hage Marianne, Kere Juha, Scheynius Annika, Söderhäll Cilla, Pershagen Göran, Komorowski Jan
Abstract excerpt
Both genetic and environmental factors are important for the development of allergic diseases. However, a detailed understanding of how such factors act together is lacking. To elucidate the interplay between genetic and environmental factors in allergic diseases, we used a novel bioinformatics approach that combines feature selection and machine learning. In two materials, PARSIFAL (a European cross-sectional...
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