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Article

Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2013

Giannoulatou Eleni, McVean Gilean, Taylor Indira B, McGowan Simon J, Maher Geoffrey J, Iqbal Zamin, Pfeifer Susanne P, Turner Isaac, Burkitt Wright Emma M M, Shorto Jennifer, Itani Aysha, Turner Karen, Gregory Lorna, Buck David, Rajpert-De Meyts Ewa, Looijenga Leendert H J, Kerr Bronwyn, Wilkie Andrew O M, Goriely Anne

Abstract excerpt

The RAS proto-oncogene Harvey rat sarcoma viral oncogene homolog (HRAS) encodes a small GTPase that transduces signals from cell surface receptors to intracellular effectors to control cellular behavior. Although somatic HRAS mutations have been described in many cancers, germline mutations cause...

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Identifiers

PMID: 24259709
DOI: 10.1073/pnas.1311381110
PMCID: PMC3864328

Genes

HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24259709-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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