Article
<i>Pseudomonas aeruginosa</i>MucD Protease Mediates Keratitis by Inhibiting Neutrophil Recruitment and Promoting Bacterial Survival
20 Nov 2013
Abstract excerpt
PURPOSE: Pseudomonas aeruginosa is a leading pathogen of blinding keratitis worldwide. In this study, the role of the serine protease in the pathogenesis of P. aeruginosa keratitis in the mouse cornea was investigated by comparing the parent and rescue strains. METHODS: Cornea of C57BL/6 mice were infected with P. aeruginosa strain PAO1, serine protease (MucD protease or PA3535) mutants (ΔmucD or ΔPA3535), or a...
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