Article
A comparative study indicates both positive and purifying selection within ryanodine receptor (RyR) genes, as well as correlated evolution.
Journal of experimental zoology. Part A, Ecological genetics and physiology - 1 Mar 2014
McKay Patrick B, Griswold Cortland K
Abstract excerpt
Ryanodine receptors are Ca(2+) ion channels that allow Ca(2+) to flow into the cytosol, from an internal store, in the form of transients. RyRs form a small gene family and vertebrates have three major isoforms, RyR1, RyR2, and RyR3, which are mixed and matched in different combinations in different tissues resulting in different Ca(2+) transients for each tissue. In this study, we characterized the interspecies...
Topics
- Calcium Channels, L-Type
- Evolution, Molecular
- Likelihood Functions
- Linear Models
- Models, Biological
- Models, Genetic
- Mutation
- Phylogeny
- Ryanodine Receptor Calcium Release Channel
- Selection, Genetic
- Species Specificity