Article
Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-α-inducing protein ofHelicobacter pylori
6 Nov 2013
Abstract excerpt
Helicobacter pylori strains produce tumor necrosis factor-α (TNF-α)-inducing protein, Tipα as a carcinogenic factor in the gastric epithelium. Tipα acts as a homodimer with 38-kDa protein, whereas del-Tipα is an inactive monomer. H. pylori isolated from gastric cancer patients secreted large amounts of Tipα, which are incorporated into gastric cancer cells by directly binding to nucleolin on the cell surface,...
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