Article
Helicobacter pylori initiates a mesenchymal transition through ZEB1 in gastric epithelial cells.
PloS one - 1 Jan 2013
Baud Jessica, Varon Christine, Chabas Sandrine, Chambonnier Lucie, Darfeuille Fabien, Staedel Cathy
Abstract excerpt
Chronic Helicobacter pylori infection provokes an inflammation of the gastric mucosa, at high risk for ulcer and cancer development. The most virulent strains harbor the cag pathogenicity island (cagPAI) encoding a type 4 secretion system, which allows delivery of bacterial effectors into gastric epithelial cells, inducing pro-inflammatory responses and phenotypic alterations reminiscent of an...
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